6533b85bfe1ef96bd12bbddb

RESEARCH PRODUCT

Covariate-constrained Randomization Routine for Achieving Baseline Balance in Cluster-randomized Trials

Sabine GabryschEva LorenzEva Lorenz

subject

Restricted randomizationmedicine.medical_specialtyRandomizationRandomization ProcedureComputer sciencelaw.invention03 medical and health sciences0302 clinical medicineMathematics (miscellaneous)Physical medicine and rehabilitationRandomized controlled triallawStatisticsCovariatemedicine030212 general & internal medicineBaseline (configuration management)Trial Arms030217 neurology & neurosurgeryBalance (ability)

description

In cluster-randomized trials, groups or clusters of individuals, rather than individuals themselves, are randomly allocated to intervention or control. In this article, we describe a new command, ccrand, that implements a covariate-constrained randomization procedure for cluster-randomized trials. It can ensure balance of one or more baseline covariates between trial arms by restriction to allocations that meet specified balance criteria. We provide a brief overview of the theoretical background, describe ccrand and its options, and illustrate it using an example.

https://doi.org/10.1177/1536867x1701700214