6533b85bfe1ef96bd12bbe2b
RESEARCH PRODUCT
false
Fernando González-candelasNuria JiménezManuela Torres-puenteInmaculada García-roblesAndrés MoyaMaría Alma Brachosubject
GeneticsbiologyOligonucleotideHepacivirusAmpliconbiology.organism_classificationVirologylaw.inventionInfectious DiseasesPhylogeneticslawVirologyGenetic variationGenetic variabilityRelative species abundancePolymerase chain reactiondescription
Background Genetic variability in viral populations is usually estimated by means of polymerase chain reaction (PCR) based methods in which the relative abundance of each amplicon is assumed to be proportional to the frequency of the corresponding template in the initial sample. Although bias in template-to-product ratios has been described before, its relevance in describing viral genetic variability at the intrapatient level has not been fully assessed yet.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2004-01-01 | Virology Journal |