Vīrusveidīgo daļiņu kā mūsdienīgu vakcīnu komponentu iegūšana raugu šūnās

6533b85cfe1ef96bd12bc30a

RESEARCH PRODUCT

Vīrusveidīgo daļiņu kā mūsdienīgu vakcīnu komponentu iegūšana raugu šūnās

Jānis Freivalds

subject

Dzīvās dabas zinātnes Bioloģija

description

Anotācija “Vīrusveidīgo daļiņu kā mūsdienīgu vakcīnu komponentu iegūšana raugu šūnās” Vīrusiem līdzīgās daļiņas (VLPs), tiek izmantotas gan fundamentālajā, gan pielietojamā zinātnē, bet galvenokārt jaunu vakcīnu izveidē. Šajā darbā raugu ekspresijas sistēma tika pielāgota (i) RNS bakteriofāgu VLP un (ii) HBc veidoto VLP iegūšanai. Tika pārbaudīta septiņu dažādu fāgu VLP veidotspēja raugos Saccharomyces cerevisiae un Pichia pastoris, respektīvi, Qβ, SP, fr, GA, AP205, PP7 un fāgam φCb5. Fermentācijas apstākļos tika panākta efektīva HBc VLP produkcija raugā P. pastoris, un tika izstrādāta efektīva attīrīšanas metode. Laboratorijas praksē tika ieviestas vēl divas raugu ekspresijas sistēmas: Kluyveromyces lactis un Hansenula polymorpha. Tika konstruēta virkne jaunu vektoru ekspresijai H. polymorpha. Atslēgvārdi: Raugi, bateriofāgi, VLP, HBV

year	journal	country	edition	language
2013-01-01

https://dspace.lu.lv/dspace/handle/7/3717

PEPhysical Sciences and Engineering
- PE2Fundamental Constituents of Matter
  - PE2_1Theory of fundamental interactions
  - PE2_2 Phenomenology of fundamental interactions
  - PE2_3Experimental particle physics with accelerators
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  - PE2_9 Electromagnetism
  - PE2_10Atomic, molecular physics
  - PE2_11Ultra-cold atoms and molecules
  - PE2_18Equilibrium and non-equilibrium statistical mechanics: steady states and dynamics
  - PE2_14Lasers, ultra-short lasers and laser physics
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- PE1Mathematics
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LSLife Sciences
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SHSocial Sciences and Humanities
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