6533b85cfe1ef96bd12bc80f

RESEARCH PRODUCT

Unexpected formation of chroman-4-ones during the synthesis of 4-hydroxymethyl-2H-chromenes from 4-aryloxybut-2-yn-1-ols

Pelayo CampsM.a LluchMaria J. ClimentMiguel A. Miranda

subject

chemistry.chemical_classificationKetoneBicyclic moleculeOrganic ChemistryPrimary alcoholBiochemistryAldehydeDiethylanilinechemistry.chemical_compoundchemistryDrug DiscoveryOrganic chemistryHydroxymethylThermal reactionAliphatic compound

description

Abstract The unexpected formation of chroman-4-ones by refluxing 4-aryloxybut-2-yn-1-ols in diethylaniline has been studied, 4-hydroxymethyl-2H-chromene and chroman-4-carboxaldehyde derivatives being established as intennediates.

https://doi.org/10.1016/s0040-4039(00)84443-3