6533b85cfe1ef96bd12bc821

RESEARCH PRODUCT

Global End-Diastolic Volume

subject

description

Global end-diastolic volume (GEDV) as determined at the bedside by the transpulmonary technique is a reliable marker of cardiac preload in critically ill patients. As shown by numerous studies, GEDV is superior to cardiac filling pressures in various settings in anesthesia and intensive care medicine in patients undergoing mechanical ventilation. Furthermore, in scenarios such as open-chest conditions, GEDV should be particularly considered and used for these purposes as dynamic parameters are associated with limitations. Clinical data from patients undergoing elective cardiac and noncardiac surgery showed that goal-directed treatment using GEDV for preload assessment is associated with the potential to reduce vasoactive drugs, gain stable metabolic conditions, and shorten the length of stay on the intensive care unit. However, further and adequately designed prospective clinical trials are required to underline and differentiate the impact of GEDV-guided hemodynamic management on the outcome of critically ill patients.