6533b85cfe1ef96bd12bc97c
RESEARCH PRODUCT
Growth control in mammalian cells by cell-cell contacts.
Sonja SchutzRenate EngelDoris RenauerR.j. WieserFranz OeschRosario HeckAnke Schäfersubject
Cell signalingGlycanbiologyCell divisionContact InhibitionHealth Toxicology and MutagenesisPublic Health Environmental and Occupational HealthContact inhibitionCell CommunicationPlatelet Membrane GlycoproteinsCell aggregationCell biologyMembrane glycoproteinsCell surface receptorbiology.proteinCell AdhesionHumansCell adhesionCell DivisionCell AggregationResearch Articledescription
Growth of normal diploid mammalian cells in vitro is strongly regulated by the actual cell density. Cell-cell contacts via specific plasma membrane glycoproteins whose glycan moieties interact with specific receptors has been found to be a main growth regulatory principle. Malignant growth is suggested to result from impaired function of these receptors.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1990-08-01 | Environmental health perspectives |