EAACI Position paper on the standardization of nasal allergen challenges.

6533b85cfe1ef96bd12bc983

RESEARCH PRODUCT

EAACI Position paper on the standardization of nasal allergen challenges.

P. Campo Mozo A. I. Giotakis Herbert Riechelmann Oliver Pfaar M. Herknerova Ralph Mösges J Mullol Adam Chaker Martin Wagenmann Nuray Bayar Muluk G. Yeryomenko K. Vogt K. Naito P. V. Tomazic Carmen Rondon I. Tasca Stephen R. Durham B. Samolinski Julia Vent Julia Vent Cemal Cingi L. Airaksinen Ludger Klimek C. La Melia Valérie Hox Philippe Gevaert Lewei Zhang P. Hellings Michael Rudenko Antonella Muraro Ioana Agache W. J. Fokkens J. Augé

subject

Allergen immunotherapy medicine.medical_specialty Nasal Provocation Tests Standardization Immunology Advisory Committees Aftercare allerginen nuha Diagnostic tools medicine.disease_cause Sneezing diagnostic tools Unmet needs Allergen challenge 03 medical and health sciences 0302 clinical medicine Allergen nasal provocation test Germany otorhinolaryngologic diseases Immunology and Allergy Medicine Humans 030223 otorhinolaryngology Intensive care medicine Anaphylaxis Administration Intranasal Skin Tests Protocol (science)allergic rhinitis business.industry altistuskoe Pruritus Nasal Sprays respiratory system Allergens Immunoglobulin E Rhinitis Allergic ta3125 Nasal Mucosa 030228 respiratory system Position paper Nasal Obstruction nasal allergen challenge business

description

DR. FARID, S.H. M.H. M. Kn. - FR FARID/0000-0003-0372-4963; Gevaert, Philippe/0000-0002-1629-8468; Hox, Valerie/0000-0003-2390-294X; Wagenman, Martin/0000-0002-9734-0241; Vent, Julia/0000-0001-5071-9580 WOS: 000438710600002 PubMed: 29377177 Nasal allergen challenge (NAC) is an important tool to diagnose allergic rhinitis. In daily clinical routine, experimentally, or when measuring therapeutic success clinically, nasal allergen challenge is fundamental. It is further one of the key diagnostic tools when initiating specific allergen immunotherapy. So far, national recommendations offered guidance on its execution; however, international divergence left many questions unanswered. These differences in the literature caused EAACI to initiate a task force to answer unmet needs and find a consensus in executing nasal allergen challenge. On the basis of a systematic review containing nasal allergen challenges of the past years, task force members reviewed evidence, discussed open issues, and studied variations of several subjective and objective assessment parameters to propose a standardized way of a nasal allergen challenge procedure in clinical practice. Besides an update on indications, contraindications, and preparations for the test procedure, main recommendations are a bilaterally challenge with standardized allergens, with a spray device offering 0.1mL per nostril. A systematic catalogue for positivity criteria is given for the variety of established subjective and objective assessment methods as well as a schedule for the challenge procedure. The task force recommends a unified protocol for NAC for daily clinical practice, aiming at eliminating the previous difficulty of comparing NAC results due to unmet needs. EAACI EAACI

year	journal	country	edition	language
2018-03-27	Allergy

10.1111/all.13416 https://pubmed.ncbi.nlm.nih.gov/29377177