6533b85cfe1ef96bd12bd237
RESEARCH PRODUCT
Studies on Regulation of the Peroxisomal β-Oxidation at the 3-Ketothiolase Step
Vijay Kumar DasariTakashi OsumiValérie Nicolas-francèsNorbert Latruffesubject
chemistry.chemical_classificationEnzymeBiochemistryPeroxisome proliferatorChemistryThiolaseCytoplasmPeroxisomeLong chainGene3-ketoacyl-CoA thiolasedescription
The peroxisomal 3-oxoacyl-CoA thiolase (thiolase) is the last enzyme involved in the β-oxidation of fatty acids. The enzyme cleaves long chain fatty acyl-CoA to generate acetyl-CoA and shortened acyl-CoA. The enzyme is nuclear encoded, synthesized in the cytoplasm and transported into peroxisomes. The thiolase B gene is inducible by the peroxisome proliferator compounds, like other genes involved in β-oxidation of fatty acids in peroxisomes.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2002-01-01 |