6533b85cfe1ef96bd12bd32e

RESEARCH PRODUCT

The metalloproteinase-disintegrin ADAM10 is exclusively expressed by type I muscle fibers.

Hans H. GoebelHans-peter HartungHelmar C. LehmannHeinz WiendlThomas DehmelBernd C. Kieseier

subject

PhysiologyADAM10Matrix metalloproteinaseCellular and Molecular NeuroscienceADAM10 ProteinPhysiology (medical)DisintegrinmedicineMyocyteHumansAdenosine TriphosphatasesMetalloproteinasebiologyMyosin Heavy ChainsMyogenesisChemistrySkeletal muscleMembrane ProteinsCell biologyADAM Proteinsmedicine.anatomical_structureMuscle Fibers Slow-TwitchBiochemistrybiology.proteinNeurology (clinical)Amyloid Precursor Protein SecretasesITGA7

description

ADAM10 (Kuzbanian) is a member of a recently discovered family of membrane-anchored metalloproteinases with a complex and conserved domain structure. In part, these metalloproteinases have been implicated in muscle formation. Herein the expression pattern of ADAM10 in human skeletal muscle was studied. ADAM10 was found to be present in human myoblasts and to be exclusively expressed in type I fibers, suggesting that it may be critical in muscle fiber differentiation.

yearjournalcountryeditionlanguage
2008-08-01Musclenerve
10.1002/mus.20972https://pubmed.ncbi.nlm.nih.gov/18642355