6533b85dfe1ef96bd12bdc72

RESEARCH PRODUCT

68Ge content quality control of 68Ge/68Ga-generator eluates and 68Ga radiopharmaceuticals – A protocol for determining the 68Ge content using thin-layer chromatography

Natalia LoktionovaElisabeth EppardFrank Rösch

subject

RadiationGenerator (computer programming)ChromatographyChemistryElutionContent (measure theory)Thin-layer chromatography

description

(68)Ge breakthrough from a (68)Ge/(68)Ga-generator appears to be one of the most critical parameters for the routine clinical application of this generator and (68)Ga-radiopharmaceuticals. We report a TLC-based (thin-layer chromatography) protocol which allows the (68)Ge breakthrough of a generator to be determined within 1 h post-initial elution. The protocol can also be adapted to allow the (68)Ge content of a (68)Ga-radiopharmaceutical preparation to be determined prior to in vivo application.

yearjournalcountryeditionlanguage
2014-09-01Applied Radiation and Isotopes
https://doi.org/10.1016/j.apradiso.2014.05.011