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RESEARCH PRODUCT
Suppression of humoral immune response against herpes simplex virus induced by defective strains, ts- and TK- mutants.
S. MüllerJürgen PodlechDietrich FalkeB. Metzgersubject
Deletion mutantGenes ViralvirusesMutantBiologymedicine.disease_causeAntibodies ViralVirus ReplicationGenomeThymidine KinaseMiceImmune systemVirologyViral InterferencemedicineImmune ToleranceAnimalsSimplexvirusRecombination GeneticDefective VirusesGeneral MedicineVirologyHerpes simplex virusHumoral immunityMutationbiology.proteinViral diseaseAntibodydescription
Suppression of humoral antibody formation against HSV is not only induced by replicating Herpes simplex virus type 2 (HSV-2) but also by the defective strain ANG and the deletion mutant 1301 of Herpes simplex virus type 1 (HSV-1). Moreover, ts-mutants A, H, K, S, 1201 and 1208 of HSV-1 as well as some ts-mutants of HSV-2 and “defective-interfering” particles of HSV-1 after high multiplicity of infection-passages induced suppression. Treatment of infected mice with ACG reduced antibody-formation but did not result in suppression. UV-irradiation of the antibody producing strain Len of HSV-1 strongly reduces antibody formation and induces suppression. Experiments using a series of intertypic recombinants showed the suppressing activity to be spread over the whole genome of HSV-2. It is concluded that suppression is induced by more than one region of the genome of HSV-2 and by incomplete replication of HSV-1 and 2.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1988-09-01 | Archives of virology |