GABA-B receptora agonista baklofēna ļoti mazo devu ietekme uz neiroiekaisuma proteīnu ekspresiju netransgēnajā AD-tipa žurku modelī

6533b85dfe1ef96bd12be1ad

RESEARCH PRODUCT

GABA-B receptora agonista baklofēna ļoti mazo devu ietekme uz neiroiekaisuma proteīnu ekspresiju netransgēnajā AD-tipa žurku modelī

subject

baklofēns GFAP Alcheimera slimība AChE Farmācija neiroiekaisums

description

Šī darba mērķis bija noteikt GABAB receptora agonista baklofēna ļoti mazo devu (0,025 un 0,05 mg/kg) efektus uz neiroiekaisumu (GFAP) un acetilholīna šķelšanu (AChE) streptozocīna (STZ) icv AD-tipa žurku modelī. Rezultāti rāda, ka: a) STZ ievadīšana izraisīja statistiski ticamu GFAP un AChE blīvuma palielinājumu smadzenēs, norādot uz neiroiekaisumu un palielinātu acetilholīna daudzuma samazināšanos b) Abās devās baklofēns aizsargāja pret STZ inducēto neiroiekaisumu, būtiski samazinot GFAP blīvumu līdz kontroles grupas rādītājiem; c) Baklofēna ievadīšana normalizēja arī STZ ievadīšanas rezultātā palielinātu acetilholīna šķelšanu. Iegūti dati liecina, ka GABAB agonista baklofēna ļoti mazās devās spēj protektēt pret neiroiekaisumu un palielināt acetilholīna līmeni ICV STZ Alcheimera slimības modeļa žurku smadzenēs. Šūnas mērķi (targets), kas realizē šos procesus paliek turpmākai noskaidrošanai. Atslēgvārdi: Alcheimera slimība, neiroiekaisums, baklofēns, GFAP, AChE

year	journal	country	edition	language
2017-01-01

https://dspace.lu.lv/dspace/handle/7/36832

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