New conditions for the generation of dianions of carboxylic acids

6533b85dfe1ef96bd12be5c8

RESEARCH PRODUCT

New conditions for the generation of dianions of carboxylic acids

Ramon Mestres Eva M. Brun Isabel Casades Salvador Gil Margarita Parra

subject

Diethylamine chemistry.chemical_classification Carboxylic acid Organic Chemistry chemistry.chemical_element Biochemistry Catalysis chemistry.chemical_compound Piperazine chemistry Drug Discovery Butyllithium Organic chemistry Lithium Octane

description

Abstract Lithium carboxylic acid enediolates are generated efficiently using lithium amides prepared from thienyllithium or butyllithium and either diethylamine, piperazine, N,N′-dibenzylethylenediamine, N-benzylpiperazine or 1,3,3-trimethyl-6-azabicyclo[3.2.1]octane, even in catalytic amounts.

year	journal	country	edition	language
1998-07-01	Tetrahedron Letters

https://doi.org/10.1016/s0040-4039(98)01050-8

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