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RESEARCH PRODUCT
Enantioselective α-alkylation of unsaturated carboxylic acids using a chiral lithium amide
Salvador GilMargarita ParraEva M. Brunsubject
Lithium amideChemistryorganic chemicalsfungiOrganic ChemistryEnantioselective synthesisDiastereomerfood and beveragesHalideAlkylationCatalysisInorganic Chemistrychemistry.chemical_compoundpolycyclic compoundsOrganic chemistryheterocyclic compoundsPhysical and Theoretical ChemistryEnantiomerdescription
Abstract The regio- and stereochemistry of the alkylation of dienediolates from unsaturated carboxylic acids with benzylic halides, which often results in mixtures of isomers, can be controlled by means of changes in the lithium amide, allowing the α-regioisomer to be obtained as the major diastereoisomer. In addition, when chiral amines are used, moderate enantiomeric excesses can be attained.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2001-04-01 | Tetrahedron: Asymmetry |