6533b85dfe1ef96bd12be71f
RESEARCH PRODUCT
ChemInform Abstract: Preparation of 5-Bromo-6-phenylimidazo[2,1-b][1,3,4]thiadiazol-2-ylamines.
Saifidin SafarovMuhamacho Amadovich KukanievElena KarpukHerbert MeierDieter SchollmeyerRahmonov Rahmonsubject
Substitution reactionchemistry.chemical_compoundchemistryStereochemistryHydrazineSubstituentGeneral MedicineCrystal structureMedicinal chemistrydescription
The reaction of primary or secondary amines with 2,5-dibromo-6-phenylimidazo[2,1-b][1,3,4]-thiadiazole (5) leads to a chemoselective replacement of the 2-Br substituent. The process represents a convenient route to the corresponding 2-ylamines 7a-d. Hydrazine reacts in an analogous fashion (5 → 7e). The structure determinations are based on an X-ray crystal structure analysis and on one- and two-dimensional NMR measurements.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2008-05-06 | ChemInform |