6533b85dfe1ef96bd12be7c5
RESEARCH PRODUCT
The aged brain: Genesis and fate of residual progenitor cells in the subventricular zone
Vivian Ecapilla-gonzalezVivian Ecapilla-gonzalezVicente Eherranz-pérezVicente Eherranz-pérezJose Manuel Egarcía-verdugoJose Manuel Egarcía-verdugosubject
AgingRostral migratory streamRostral migratory streamNeurogenesisSubventricular zoneReviewBiologylcsh:RC321-571Cellular and Molecular NeurosciencemedicineSubependymal zoneCell migrationlcsh:Neurosciences. Biological psychiatry. NeuropsychiatryNeural stem cellsNeurogenesissubventricular zonesubventricular zone (SVZ)Neural stem cellNeuroepithelial cellmedicine.anatomical_structurenervous systemOligodendrogenesisStem cellNeuroscienceAdult stem cellNeurosciencedescription
Neural stem cells (NSCs) persist in the adult mammalian brain through life. The subventricular zone (SVZ) is the largest source of stem cells in the nervous system, and continuously generates new neuronal and glial cells involved in brain regeneration. During aging, the germinal potential of the SVZ suffers a widespread decline, but the causes of this turn down are not fully understood. This review provides a compilation of the current knowledge about the age-related changes in the NSC population, as well as the fate of the newly generated cells in the aged brain. It is known that the neurogenic capacity is clearly disrupted during aging, while the production of oligodendroglial cells is not compromised. Interestingly, the human brain seems to primarily preserve the ability to produce new oligodendrocytes instead of neurons, which could be related to the development of neurological disorders. Further studies in this matter are required to improve our understanding and the current strategies for fighting neurological diseases associated with senescence.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2015-09-24 |