6533b85efe1ef96bd12bf3b7

RESEARCH PRODUCT

DNA-binding of nickel(II), copper(II) and zinc(II) complexes: structure-affinity relationships

José M. LealNatalia BustoAntonino LauriaAnna Maria AlmericoAlessio TerenziGiampaolo BaroneBegoña García

subject

DenticityMetal ions in aqueous solutionInorganic chemistryBinding constantchemistry.chemical_elementZincDNABinding constantCopperSettore CHIM/08 - Chimica FarmaceuticaInorganic ChemistryNickelCrystallographyZincchemistryNickelSettore CHIM/03 - Chimica Generale E InorganicaMaterials ChemistryChelationPhysical and Theoretical ChemistryCopperCoordination geometry

description

Abstract Nickel(II), copper(II) and zinc(II) complexes with the same ligands normally display analogous coordination geometry and binding mode toward DNA. However, although qualitatively alike in structure and properties, different DNA-binding ability has often been observed. This review surveys the most recent examples of binding of the three metal ions complexed with monodentate and chelating bidentate to tetradentate ligands to DNA. An attempt has also been made to rationalize the observed trend in the values of the intrinsic DNA-binding constant, Kb, in terms of structural and chemical features.

yearjournalcountryeditionlanguage
2013-10-01
10.1016/j.ccr.2013.02.023http://hdl.handle.net/10447/99982