Jauna dihidropiridīna atvasinājuma AV-6-93 efekts uz biomarķiera BDNF ekspresiju stresa modelī žurkām

6533b85efe1ef96bd12bf6bc

RESEARCH PRODUCT

Jauna dihidropiridīna atvasinājuma AV-6-93 efekts uz biomarķiera BDNF ekspresiju stresa modelī žurkām

subject

hipokamps BDNF žurkas imobilizācijas stress zāļu viela AV-6-93 Farmācija

description

Stresa izraisītie atmiņas bojājumi ir iemesls jaunu zāļu vielu meklējumiem, kas spētu aizkavēt smadzeņu bojājumus. Mūsu pētījuma mērķis bija noteikt jauna Latvijas Organiskās sintēzes institūtā sintezētās zāļu vielas AV-6-93, kas sastāv no dihidropiridīna un adamantāna atvasinājumiem, ietekmi uz neirotrofā faktora BDNF ekspresiju imobilizācijas stresētām žurkām hipokampā ar Western blota metodi. Petījuma rezultāti rāda, ka imobilizācijas stress ir palielinājis BDNF ekspresiju žurku hipokampā salīdzinājumā ar kontroles hipokampa žurkām, un AV-6-93 piemīt spēja normalizēt BDNF ekspresiju stresēto žurku hipokampā. Mūsu dati rāda, ka nepieciešams turpināt pētīt šī savienojuma molekulāros mehānismus, lai noskaidrotu tā neiroprotektīvās īpašības.

year	journal	country	edition	language
2015-01-01

https://dspace.lu.lv/dspace/handle/7/30823

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