6533b85efe1ef96bd12bfc2a

RESEARCH PRODUCT

Designed biodegradable hydrogel structures prepared by stereolithography using poly(ethylene glycol)/poly(D,L-lactide)-based resins

Dirk W. GrijpmaFerry P.w. MelchelsTetsu M. SeckTetsu M. SeckJan Feijen

subject

IR-80283Materials scienceStereolithographyPolyestersPharmaceutical ScienceDesigned porous structuresSCAFFOLDSHydrogel Polyethylene Glycol Dimethacrylatelaw.inventionPolyethylene GlycolsMacromer photo-polymerisationCONSTRUCTSchemistry.chemical_compoundMETIS-272859lawPolymer chemistryGLYCOL)Cell Adhesionmacromer photopolymerisationHumansTissue engineeringPorosityStereolithographyAqueous solutiontechnology industry and agricultureMesenchymal Stem CellsMacromonomerResins SyntheticPhotopolymerBiodegradation EnvironmentalchemistryChemical engineeringBiodegradable hydrogelsSelf-healing hydrogelsCELLS090301 BiomaterialsEthylene glycolGyroid

description

Designed three-dimensional biodegradable poly(ethylene glycol)/poly(D,L-lactide) hydrogel structures were prepared for the first time by stereolithography at high resolutions. A photo-polymerisable aqueous resin comprising PDLLA-PEG-PDLLA-based macromer, visible light photo-initiator, dye and inhibitor in DMSO/water was used to build the structures. Porous and non-porous hydrogels with well-defined architectures and good mechanical properties were prepared. Porous hydrogel structures with a gyroid pore network architecture showed narrow pore size distributions, excellent pore interconnectivity and good mechanical properties. The structures showed good cell seeding characteristics, and human mesenchymal stem cells adhered and proliferated well on these materials. (C) 2010 Elsevier B.V. All rights reserved.

yearjournalcountryeditionlanguage
2010-11-20
10.1016/j.jconrel.2010.07.111https://research.rug.nl/en/publications/2e30a59d-4893-4c3d-852e-18b690e17448