6533b85efe1ef96bd12bfc3e
RESEARCH PRODUCT
Inhalation pharmacokinetics based on gas uptake studies. IV. The endogenous production of volatile compounds.
H. M. BoltJ. G. Filsersubject
MaleChromatographyInhalationTrichloroethyleneVinyl bromideHealth Toxicology and MutagenesisEndogenyRats Inbred StrainsGeneral MedicineMetabolismToxicologyModels BiologicalRatsAcetonechemistry.chemical_compoundKineticschemistryPharmacokineticsAcetoneOrganic chemistryAnimalsGasesVolatilizationXenobioticdescription
A pharmacokinetic description of production, distribution and metabolism of endogenous volatile compounds is presented. This description uses the "gas uptake model" of a closed recirculated atmosphere in which experimental animals are exposed. As an example, the production rates of acetone, under different conditions of stimulation by xenobiotics, are calculated from published experimental data. The theoretical descriptions may serve as a basis for treating the problem of hydrocarbon exhalation in toxicological experiments with compounds eliciting lipid peroxidation.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1983-02-01 | Archives of toxicology |