6533b85efe1ef96bd12bfcc9
RESEARCH PRODUCT
Platelet Phenotyping and Function Testing in Thrombocytopenia.
Yavar ShiravandKerstin Jurksubject
medicine.medical_specialtyPlatelet disorderlcsh:MedicinethrombocytopeniaReview030204 cardiovascular system & hematology03 medical and health sciences0302 clinical medicineplatelet function testsmedicineplatelet disordersPlateletAcquired thrombocytopeniaIntensive care medicineReduced platelet countbusiness.industryflow cytometrylcsh:RGeneral Medicineplatelet countbleedingClinical PracticeFunction analysisPlatelet function testbusiness030215 immunologydescription
Patients who suffer from inherited or acquired thrombocytopenia can be also affected by platelet function defects, which potentially increase the risk of severe and life-threatening bleeding complications. A plethora of tests and assays for platelet phenotyping and function analysis are available, which are, in part, feasible in clinical practice due to adequate point-of-care qualities. However, most of them are time-consuming, require experienced and skilled personnel for platelet handling and processing, and are therefore well-established only in specialized laboratories. This review summarizes major indications, methods/assays for platelet phenotyping, and in vitro function testing in blood samples with reduced platelet count in relation to their clinical practicability. In addition, the diagnostic significance, difficulties, and challenges of selected tests to evaluate the hemostatic capacity and specific defects of platelets with reduced number are addressed.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2021-03-01 | Journal of clinical medicine |