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RESEARCH PRODUCT

How to Predict the Suitability for Corneal Donorship?

Joanna Wasielica-poslednikAlexander K. SchusterMelissa ApelNorbert PfeifferJulia Bing BuAlicia PoplawskiFranziska SchönAdrian Gericke

subject

0301 basic medicinemedicine.medical_specialtygenetic structuressuitability for transplantationmedicine.medical_treatmentcorneal graftContext (language use)Articledeath-to-explantation interval03 medical and health sciences0302 clinical medicineOphthalmologyMedicineCardiopulmonary resuscitationcorneal bankingMale genderCause of deathbusiness.industryendothelial cell densityLens StatusREye bankGeneral Medicinedonor corneaeye diseasesTransplantationEndothelial cell density030104 developmental biology030221 ophthalmology & optometryMedicinesense organsbusiness

description

Background: In Germany, more than one-third of donor corneas harvested are not suitable for transplantation. We evaluated the factors associated with the usability of donor corneas. Method: Data from 2032 consecutive donor corneas harvested at the Rhineland-Palatinate Eye Bank in Mainz, Germany, were retrospectively analyzed. Factors of interest were age, sex, lens status, cause of death, cardiopulmonary resuscitation (CPR), death-to-explantation-interval (DEI), and the influence of these factors on the proportion of discarded donor corneas. Factors associated with endothelial cell density (ECD) were analyzed in a linear regression mixed model. Results: Higher donor age, male gender, pseudophakic lens status, and longer DEI were associated with significantly reduced ECD. With respect to DEI, the estimated cell loss was 7 ± 2 cells/mm2/hour (p &lt

yearjournalcountryeditionlanguage
2021-07-31Journal of Clinical Medicine
10.3390/jcm10153426https://www.mdpi.com/2077-0383/10/15/3426