6533b85efe1ef96bd12bff5f

RESEARCH PRODUCT

Hepatocyte transplantation, a step forward?

Michael OttJosé V. Castell

subject

surgical procedures operativeHepatocyte transplantationHepatologybusiness.industryMEDLINEMedicineTrasplantació d'òrgans teixits etc.businessBioinformaticsGastroenterologia

description

Hepatocyte transplantation emerged a few decades ago as a possible strategy to overcome some of the limitations of liver transplantation, among them the availability of organ donors and the functional quality of grafts. Nowadays, allogenic cell transplantation is still to be confirmed as a viable therapeutic option for patients with hereditary metabolic liver diseases. Although we have now overseen 5 decades of basic and animal research in the field, the number of successfully treated patients remains low. Limitations in cell engraftment and selective proliferation of transplanted cells remain a constraint to the generalized use of this therapeutic approach.

yearjournalcountryeditionlanguage
2019-06-01Journal of Hepatology
https://doi.org/10.1016/j.jhep.2019.03.022