6533b85efe1ef96bd12c0725
RESEARCH PRODUCT
Diet and Immunosenescence
Giulia AccardiBalistrericarmela RitaCalogero CarusoCandoregiuseppinasubject
Settore MED/04 - Patologia GeneralebiologyMediterranean dietbusiness.industryCalorie restrictionImmunosenescenceGut florabiology.organism_classificationUnbalanced dietImmune systemImmunityAgeingImmunologyageing diet immunosenescenceMedicineSettore MED/05 - Patologia Clinicabusinessdescription
Ageing is a systemic condition leading to a gradual loss of molecular and cellular fidelity. A feature of ageing is immunosenescence, consisting in several modifications that increase morbidity and mortality in elderly. Environment, genetic background, immune system, and intestinal microbiota play a fundamental role in immunosenescence. The development of a chronic, low-grade, inflammatory status, known as “inflamm-ageing,” is a typical aspect of immunosenescence mostly due to the pro-inflammatory cytokine production linked to the chronic antigenic load. Nutrition can act on ageing, immunity, and health in general. Unbalanced diet with an insufficient intake of micro- and macronutrient and vitamins is a major nutritional problem among elderly, resulting in a dramatic change in gut microbiota. Calorie restriction and long-term adherence to Mediterranean diet could prevent or manage age-related diseases and immunosenescence.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2013-11-04 |