Determination of optical purity of phosphonic acid analogues of aromatic amino acids by capillary electrophoresis with alpha-cyclodextrin.

6533b85efe1ef96bd12c07ff

RESEARCH PRODUCT

Determination of optical purity of phosphonic acid analogues of aromatic amino acids by capillary electrophoresis with alpha-cyclodextrin.

Paweł Kafarski Paweł Kafarski Piotr Wieczorek Paweł Dżygiel Ewa Rudzińska

subject

chemistry.chemical_classification Cyclodextrins alpha-Cyclodextrins Chromatography Cyclodextrin Organic Chemistry Organophosphonates Electrophoresis Capillary Phenylalanine General Medicine Biochemistry Analytical Chemistry Amino acid chemistry.chemical_compound Capillary electrophoresis chemistry Benzene derivatives Aromatic amino acids phosphonic acids Enantiomer enantiomer separation Amino Acids Enantiomeric excess

description

A simple and efficient method for the determination of enantiomeric purity of structurally diverse phosphonic and phosphinic acid analogues of phenylalanine and phenylglycine using capillary electrophoresis is presented. These preliminary studies indicated that the enantiomer separation is strongly dependent on the structure of the aminophosphonic acid.

year	journal	country	edition	language
2000-10-01	Journal of chromatography. A

10.1016/s0021-9673(00)00465-9 https://pubmed.ncbi.nlm.nih.gov/11105875

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