6533b85efe1ef96bd12c0891
RESEARCH PRODUCT
Dehydrogenative Anodic C−C Coupling of Phenols Bearing Electron‐Withdrawing Groups
Siegfried R. WaldvogelJohannes L. RöcklRobert FrankeDieter Schollmeyersubject
Denticityoxidation010405 organic chemistryChemistrySupporting electrolyteCommunicationC−C couplingoxygen heterocyclesSubstrate (chemistry)General Chemistry010402 general chemistryElectrochemistry01 natural sciencesEnvironmentally friendlyCombinatorial chemistryCommunicationsCatalysisCoupling reaction0104 chemical scienceschemistry.chemical_compoundElectrochemistry | Hot Paperelectrochemistrycross-couplingPolar effectPhenolsdescription
Abstract We herein present a metal‐free, electrosynthetic method that enables the direct dehydrogenative coupling reactions of phenols carrying electron‐withdrawing groups for the first time. The reactions are easy to conduct and scalable, as they are carried out in undivided cells and obviate the necessity for additional supporting electrolyte. As such, this conversion is efficient, practical, and thereby environmentally friendly, as production of waste is minimized. The method features a broad substrate scope, and a variety of functional groups are tolerated, providing easy access to precursors for novel polydentate ligands and even heterocycles such as dibenzofurans.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2019-11-19 | Angewandte Chemie International Edition |