6533b85efe1ef96bd12c0a9b
RESEARCH PRODUCT
Formal synthesis of ent-Cephalotaxine using a one-pot Parham-aldol sequence
Juha SiitonenLu YuJakob DanielssonGiovanni Di GregorioPeter Somfaisubject
kemiallinen synteesialkaloiditluonnonaineetformal synthesisdescription
A short formal synthesis of ent-Cephalotaxine is achieved. The approach features a new Lewis acid mediated [2,3]-Stevens rearrangement of N-allylated prolineamide to generate a key quaternary stereogenic center. Additionally, a one-pot Parham–aldol sequence was developed to rapidly assembly two of the four rings in the cephalotaxine core. peerReviewed
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2018-01-01 |