Seruma amiloīda A līmeņa korelācija ar slimības aktivitāti pacientiem ar iekaisīgajām zarnu slimībām

6533b85efe1ef96bd12c0be6

RESEARCH PRODUCT

Seruma amiloīda A līmeņa korelācija ar slimības aktivitāti pacientiem ar iekaisīgajām zarnu slimībām

Artjoms Baharevs

subject

Krona slimība slimības aktivitāte seruma amiloīds A biomarķieris čūlainais kolīts Medicīna

description

IZS ir raksturīga intermitējoša gaita, tāpēc šos slimniekus ir nepieciešams izvērtēt bieži un precīzi. Diemžēl ar invazīvām metodēm slimības aktivitāte tiek izvērtēta pārāk reti, tāpēc ir nepieciešami minimāli invazīvi biomarķieri, kurus kombinējot ar citiem diagnostiskajiem kritērijiem varētu efektīvi izvērtēt un kontrolēt IZS slimības aktivitāti Darba mērķis bija noteikt seruma amiloīda A (SAA) saistību ar klīniskajiem, endoskopiskajiem kritērijiem un laboratoriskajiem mērījumiem pacientiem ar IZS aktīvajā un neaktīvajā slimības fāze. Viena centra prospektīvā pilot pētījumā tika iesaistīti 37 pacienti, 15 pacienti ar KS un 22 pacienti ar ČK. Tika noteikti SAA līmeņi ČK un KS grupās aktīvajās un neaktīvajās grupās un tika meklēta korelācija ar klīniskajiem, endoskopiskajiem indeksiem un CRO. Rezultāti parāda, ka SAA, ir nozīmīgi palielināts IZS aktīvās slimības grupās un ir atrasta korelācija ar klīniskajiem un endoskopiskajiem indeksiem un CRO.

year	journal	country	edition	language
2016-01-01

https://dspace.lu.lv/dspace/handle/7/34266

PEPhysical Sciences and Engineering
- PE2Fundamental Constituents of Matter
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  - PE2_2 Phenomenology of fundamental interactions
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  - PE2_16Non-linear physics
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SHSocial Sciences and Humanities
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