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RESEARCH PRODUCT
Microenvironment-centred dynamics in aggressive B-cell lymphomas.
Mario P. ColomboMarco CalvarusoVito FrancoCarla GuarnottaAda Maria FlorenaSabina SangalettiClaudio TripodoMatilde Cacciatoresubject
Stromal cellMicroenvironmentHematologyReview ArticleBiologyMicroenvironment; aggressive B-cell lymphomasCrosstalk (biology)Immune systemmedicine.anatomical_structureImmunologymedicineDiseases of the blood and blood-forming organsRC633-647.5Indolent lymphomasB cellaggressive B-cell lymphomasdescription
Aggressive B-cell lymphomas share high proliferative and invasive attitudes and dismal prognosis despite heterogeneous biological features. In the interchained sequence of events leading to cancer progression, neoplastic clone-intrinsic molecular events play a major role. Nevertheless, microenvironment-related cues have progressively come into focus as true determinants for this process. The cancer-associated microenvironment is a complex network of nonneoplastic immune and stromal cells embedded in extracellular components, giving rise to a multifarious crosstalk with neoplastic cells towards the induction of a supportive milieu. The immunological and stromal microenvironments have been classically regarded as essential partners of indolent lymphomas, while considered mainly negligible in the setting of aggressive B-cell lymphomas that, by their nature, are less reliant on external stimuli. By this paper we try to delineate the cardinal microenvironment-centred dynamics exerting an influence over lymphoid clone progression in aggressive B-cell lymphomas.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2012-01-01 |