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RESEARCH PRODUCT
Work-Related Stress, Physio-Pathological Mechanisms, and the Influence of Environmental Genetic Factors
Tiziana RamaciFulvio PlesciaEmanuele CannizzaroLuigi Cirrincionesubject
Health Toxicology and Mutagenesislcsh:MedicineWork related stressReviewBiologyEpigenesis GeneticFight-or-flight responsestressOccupational Stress03 medical and health sciences0302 clinical medicineHumans030212 general & internal medicineEpigeneticsPathologicalSettore MED/44 - Medicina Del Lavorolcsh:RPublic Health Environmental and Occupational Healthgenetic factorwork-related streExperimental researchSystematic reviewwork-related stressSettore BIO/14 - Farmacologiagenetic factorsenvironmentNeuroscience030217 neurology & neurosurgerydescription
Work-related stress is a growing health problem in modern society. The stress response is characterized by numerous neurochemicals, neuroendocrine and immune modifications that involve various neurological systems and circuits, and regulation of the gene expression of the different receptors. In this regard, a lot of research has focused the attention on the role played by the environment in influencing gene expression, which in turn can control the stress response. In particular, genetic factors can moderate the sensitivities of specific types of neural cells or circuits mediating the imprinting of the environment on different biological systems. In this current review, we wish to analyze systematic reviews and recent experimental research on the physio-pathological mechanisms that underline stress-related responses. In particular, we analyze the relationship between genetic and epigenetic factors in the stress response.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2019-10-01 | International Journal of Environmental Research and Public Health |