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RESEARCH PRODUCT
Effects of Regulatory T Cell–Dendritic Cell Interactions on Adaptive Immune Responses
Hansjörg SchildHans Christian ProbstStefan TenzerMarkus P. RadsakMichael StassenTobias BoppEdgar Schmittsubject
Regulatory T cellbusiness.industrymedicine.medical_treatmentT cellPeripheral toleranceDendritic cellImmunotherapyVaccinationmedicine.anatomical_structureImmune systemImmunityCancer researchmedicinebusinessdescription
The limited efficacy of chemo- or radiotherapy against neoplasias necessitates the development of complementary therapeutic strategies. Tumor immunotherapy represents a promising approach as it harnesses the potential of the host immune system to recognize and eradicate transformed cells. So far, T cell-based immunotherapy still suffers from a striking discrepancy between the induction of tumor-specific immune responses in experimental settings and therapeutic immunity in clinically relevant conditions. However, therapeutic approaches targeting immune regulatory mechanisms have lately shown encouraging results and have initiated long-lasting tumor control in patients. Therefore, a deeper understanding of these mechanisms and their role in tumor development and growth is desirable. The therapeutic manipulation of immune regulatory mechanisms represents a complementary and synergistic approach to antigen-specific vaccination strategies.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2014-01-01 |