6533b85ffe1ef96bd12c1de4
RESEARCH PRODUCT
Conformational studies of the Emp-AKH peptide using Molecular and Langevin Dynamics methods
Igor Z. Zubrzyckisubject
chemistry.chemical_classificationMolecular dynamicsComputational chemistryChemistryPeptideLangevin dynamicsGeneral Biochemistry Genetics and Molecular Biologydescription
The secondary structure of the member of the AKH/RPCH family has been studied by Molecular Dynamics and Langevin Dynamics methods. Molecular dynamics simulation were performed in vacuum, model aqueous solution and simulated membrane. Langevin dynamics simulation was performed using the friction factor γ equal to 2 ps-1. Molecular dynamics as well as Langevin Dynamics simulation were conducted at 300 K. All minimum energy conformers have similar backbone structure characterised by the turn consisted out of 3 amino acids, Thr, Pro and Asn7. Structures obtained from Molecular Dynamics simulation are characterised by the lack of hydrogen bonds whereas the structure obtained form Langevin Dynamics simulation is stabilised by the web of hydrogen bonds.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1998-10-01 |