6533b85ffe1ef96bd12c23d6
RESEARCH PRODUCT
Synthesis of pyrido[2,3-d]pyrimidinones by the reaction of aminopyrimidin-4-ones with benzylidene meldrum's acid derivatives
Adolfo SánchezBraulio InsuastyManuel NoguerasHerbert MeierAngelina HormazaNorbert HanoldJairo Quirogasubject
Nitrobenzenechemistry.chemical_compoundPyrimidinoneschemistryBoilingOrganic ChemistryOrientation (graph theory)Meldrum's acidMedicinal chemistrydescription
A series of pyrido[2,3-d]pyrimidine-4,7-diones 5a-h were prepared from 6-amino-4-pyrimidones 1 and benzylidene Meldrum's acid derivatives 2 by cyclization reactions in boiling nitrobenzene. The structure of 5, determined by nmr measurements, reveals a selective orientation of 1 and 2 in the addition step.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1997-03-01 | Journal of Heterocyclic Chemistry |