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RESEARCH PRODUCT
ChemInform Abstract: Lithium Enediolates and Dienediolates of Carboxylic Acids in Synthesis: Alkylation with Secondary Halides.
Ramon MestresSalvador GilMargarita ParraEva M. Brunsubject
chemistry.chemical_classificationElimination reactionchemistryDouble bondchemistry.chemical_elementHalidelipids (amino acids peptides and proteins)LithiumStereoselectivityRather poorGeneral MedicineAlkylationMedicinal chemistrydescription
Abstract High yields in the alkylation of dianions of α,β-unsaturated carboxylic acids with secondary halides can be obtained despite elimination reactions occurring. α-Regioselectivity for the alkylation of but-2-enoic acids ( 1–4 ) is seldom obtained. Although double bond stereoselectivity is higher than 99% for γ-alkylated products, stereoselectivity is rather poor for most of the α-alkylated products.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2010-06-16 | ChemInform |