The effect of probiotics on the genotoxicity of furazolidone.

6533b85ffe1ef96bd12c2740

RESEARCH PRODUCT

The effect of probiotics on the genotoxicity of furazolidone.

J. Raipulis P. Semjonovs M. Toma

subject

Furazolidone Bifidobacterium lactis medicine.disease_cause Microbiology Microbiology law.invention Probiotic Lactobacillus acidophilus law medicine SOS Response Genetics Escherichia coli biology Mutagenicity Tests Probiotics Furazolidone General Medicine biology.organism_classification SOS chromotest Lactobacillus Anti-Infective Agents Local bacteria Bifidobacterium Bacteria Genotoxicity Food Science medicine.drug

description

Antigenotoxic activity of probiotic bacteria against furazolidone was studied using the short-term bacterial assay SOS chromotest, with Escherichia coli PQ37 as the test organism. The supernatants from probiotic and furazolidone co-incubation exhibited rather strong suppression on SOS induction produced by furazolidone on E. coli PQ 37 (sfiA: lacZ). Genotoxicity inhibition was found for all strains of the examined bacteria belonging to three genera. The highest genotoxicity inhibition was detected for Bifidobacterium lactis Bb-12 (92.0%) and for Lactobacillus acidophilus T20 (81.9%).

year	journal	country	edition	language
2004-04-02	International journal of food microbiology

10.1016/j.ijfoodmicro.2004.11.029 https://pubmed.ncbi.nlm.nih.gov/16014301

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