6533b860fe1ef96bd12c2e12

RESEARCH PRODUCT

ChemInform Abstract: 1,2,4-Oxadiazole Rearrangements Involving an NNC Side-Chain Sequence.

Nicolò VivonaAndrea PaceSilvestre BuscemiAntonio Palumbo Piccionello

subject

chemistry.chemical_compoundchemistryStereochemistryTriazole derivativesSide chainOxadiazoleGeneral MedicineSequence (medicine)

description

The thermal rearrangement of N-1,2,4-oxadiazol-3-yl-hydrazones into 1,2,4-triazole derivatives is reported. This represents the first example of a three-atom side-chain rearrangement involving an NNC sequence linked at the C(3) of the oxadiazole. The reactions carried out under solvent-free conditions produced good to high yields of the final products.

https://doi.org/10.1002/chin.201004128