6533b860fe1ef96bd12c2f52
RESEARCH PRODUCT
Pyrazolo[3,4-d][1,2,3]triazolo[1,5-a]pyrimidine: a new ring system through Dimroth rearrangement
Arturo SilvestriAntonino LauriaIlenia AbbateAnna Maria AlmericoGiampaolo BaroneNoemi GambinoChiara Patellasubject
13-dipolar cycloaddition Dimroth rearrangement docking studies DNA intercalating agentsPyrimidineChemistryStereochemistryOrganic ChemistryIntercalation (chemistry)Settore CHIM/06 - Chimica OrganicaRing (chemistry)BiochemistryDimroth rearrangementSettore CHIM/08 - Chimica FarmaceuticaD-1chemistry.chemical_compoundDrug DiscoveryDNAdescription
Abstract Derivatives of the new ring system pyrazolo[3,4- d ][1,2,3]triazolo[1,5- a ]pyrimidine were synthesized from the corresponding angular isomers, through a Dimroth rearrangement, in quantitative yields. Preliminary computational studies demonstrated that this class of compounds could be a good candidate as DNA intercalating agents.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2008-08-01 |