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RESEARCH PRODUCT
La prise de biotine à fortes doses : une cause d’hyperthyroïdie biologique factice
Benjamin BouilletA. Roulandsubject
[SDV] Life Sciences [q-bio]030213 general clinical medicine03 medical and health sciences0302 clinical medicine[SDV]Life Sciences [q-bio]030220 oncology & carcinogenesisGastroenterologyInternal Medicine3. Good healthdescription
IntroductionMany hormone immunoassays use the biotin streptavidin interaction to immobilize immune complexes. The intake of high dose biotin can interfere with immunoassays using the biotin streptavidin interaction. The biotin-immunoassay interference generates falsely low or falsely high tests of hormones according to the type of immunoassay used.Case reportA 70-year-old patient, with progressive multiple sclerosis, was referred to our hospital for thyrotoxicosis. She was found to have markedly elevated thyroid hormones level (T3-T4) and decreased thyrotropin (TSH) level but she had no symptoms of hyperthyroidism. An ingestion of biotin, that is more and more frequent in patients with progressive multiple sclerosis, was found. Thyroid function tests normalized after discontinuation of biotin treatment.ConclusionThe discrepancy between a clinical exam which is not indicative of thyrotoxicosis and markedly abnormal thyroid function tests should lead to a
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2020-02-29 | La Revue de Médecine Interne |