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RESEARCH PRODUCT
Catalytic Asymmetric Addition of Dimethylzinc to α-Ketoesters, Using Mandelamides as Ligands
Gonzalo BlayJosé R. PedroIsabel FernándezAlicia Marco‐aleixandresubject
Molecular StructureChemistryLigandOrganic ChemistryDimethylzincEstersStereoisomerismAlcoholGeneral MedicineLigandsBiochemistryCombinatorial chemistryCatalysisCatalysisZincchemistry.chemical_compoundDeprotonationReagentMandelic AcidsOrganic chemistryPhysical and Theoretical Chemistrydescription
[reaction: see text] A strategy based on the control of the electron-donating capabilities of the coordinating groups of the ligand has been applied in the catalytic asymmetric addition of organometallic reagents to ketoesters. Mandelamides having deprotonated alcohol and carboxyamido groups catalyzed the addition of dimethylzinc to alpha-ketoesters with good yields and ee (up to 90%).
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2006-03-28 | Organic Letters |