6533b860fe1ef96bd12c39e3

RESEARCH PRODUCT

The reaction of 2,4,5,6-tetraaminopyrimidine with chalcones

Braulio InsuastyDiego Luis GonzálezHerbert MeierJairo QuirogaAlfredo Perez

subject

chemistry.chemical_compoundAcetic acidDiazepinechemistryOrganic ChemistryOrganic chemistryCondensation reactionCatalysis

description

The reaction of the tetraaminopyrimidine 1 with the chalcones 2a-f yields, in the presence of catalytic amounts of acetic acid, the 1H-pyrimido[4,5-b][1,4]diazepine derivatives 3a-f. The cyclization process consists of a condensation reaction and a Michael type addition.

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