6533b860fe1ef96bd12c3a78
RESEARCH PRODUCT
Catalytic Enantioselective Cyclopropylalkynylation of Aldimines Generated In Situ from α-Amido Sulfones
Alicia MonleonGonzalo BlayJosé R. Pedrosubject
Organic ChemistryPharmaceutical ScienceStereoisomerismCatalysisAnalytical ChemistryZinc<i>N</i>-carbamoyl-protected propargylic amines; α-amido sulfones; cyclopropylacetylene; BINOL; zinc complexCatàlisiChemistry (miscellaneous)Drug DiscoveryMolecular MedicineSulfonesAminesPhysical and Theoretical ChemistryQuímica orgànicadescription
A convenient procedure of synthesis of N-carbamoyl-protected propargylic amines substituted with a cyclopropyl group from α-amido sulfones and cyclopropylacetylene is described. The reaction is catalyzed by a chiral BINOL-type zinc complex and provides the corresponding products in good yields and enantioselectivities.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2022-06-11 |