6533b860fe1ef96bd12c3bb6

RESEARCH PRODUCT

Eight-membered heterocycles with two heteroatoms in a 1,3-relationship of interest in medicinal chemistry

Girolamo CirrincioneDaniela CarbonePatrizia DianaCamilla PecoraroBarbara ParrinoStella Cascioferro

subject

ChemistryHeteroatomEight-membered heterocycles with two heteroatoms 13 Medicinal chemistry Biological activity 13-Diazocines 13-Oxazocines 13-Thiazocines 13-Dioxocins 13-Oxathiocins 13-DithiocinsSettore CHIM/08 - Chimica FarmaceuticaMedicinal chemistry

description

This chapter deals with 1,3-diheterocines, eight-membered heterocyclic systems with two heteroatoms, N, O and S, in a 1,3 relationship, exhibiting biological properties and exhaustively covers the literature from 2007 to the end of November 2019. The biological results of 1,3-diazocines, 1,3-oxazocines, 1,3-dioxocins and 1,3-thiazocines, that are the largest class of 1,3-diheterocines, were collected together with the few results available for 1,3-oxathiocin and 1,3-dithiocin derivatives at that time.

https://doi.org/10.1016/bs.aihch.2020.11.001