6533b861fe1ef96bd12c428e
RESEARCH PRODUCT
Reactivity difference between diphosgene and phosgene in reaction with (2,3-anti)-3-amino-1,2-diols
Salvador GilEl Mestafa El HadramiElena Zaballos-garcíaRamón J. ZaragozáJosé Sepúlveda-arquesA. Hamdachsubject
Reaction conditionschemistry.chemical_compoundchemistryReagentOrganic ChemistryDrug DiscoveryDiphosgeneOrganic chemistryReactivity (chemistry)PhosgeneBiochemistrydescription
In reactions of (2,3-anti)-3-amino-1,2-diols with diphosgene and phosgene and their conversion into 1,3-oxazolidin-2-ones, some differences in the stereochemistry of the reactions have been found with these two reagents. The reactions with phosgene afforded the expected cis-oxazolidinones, and in the reaction with diphosgene under the same reaction conditions, the trans-oxazolidinones were also obtained.
year | journal | country | edition | language |
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2006-06-01 | Tetrahedron |