6533b861fe1ef96bd12c4359

RESEARCH PRODUCT

Untargeted Metabolomics Used to Describe the Chemical Composition, Antioxidant and Antimicrobial Effects of Extracts from Pleurotus spp. Mycelium Grown in Different Culture Media

Giancarlo Angeles FloresCarolina Elena GiromettaGaia CusumanoPaola AngeliniBruno TirilliniFederica IanniFrancesca BlasiLina CossignaniRoberto Maria PellegrinoCarla EmilianiRoberto VenanzoniGiuseppe VenturellaPasqualina ColasuonnoFortunato CirlincioneMaria Letizia GarganoGokhan ZenginAlessandra AcquavivaSimonetta Cristina Di SimoneGiustino OrlandoLuigi MenghiniClaudio Ferrante

subject

Microbiology (medical)Pleurotus speciePleurotus speciesphenolic compoundsmetabolomicsBiochemistryMicrobiologyInfectious Diseases<i>Pleurotus species</i>; metabolomics; antimicrobial effect; phenolic compoundsantimicrobial effectSettore BIO/03 - Botanica Ambientale E ApplicataPleurotus species; metabolomics; antimicrobial effect; phenolic compoundsPharmacology (medical)General Pharmacology Toxicology and Pharmaceuticsmetabolomic

description

Pleurotus species isolated in vitro were studied to determine the effect of different media on their production of secondary metabolites, antimicrobial, and antioxidant activity. The different metabolites among Pleurotus samples covered a total of 58 pathways. Comparisons were made between the metabolic profiles of Pleurotus spp. mycelia grown in two substrates: Potato-dextrose-agar-PDA, used as control (S1), and PDA enriched with 0.5 % of wheat straw (S2). The main finding was that the metabolic pathways are strongly influenced by the chemical composition of the growth substrate. The antibacterial effects were particularly evident against Escherichia coli, whereas Arthroderma curreyi (CCF 5207) and Trichophyton rubrum (CCF 4933) were the dermatophytes more sensitive to the mushroom extracts. The present study supports more in-depth investigations, aimed at evaluating the influence of growth substrate on Pleurotus spp. antimicrobial and antioxidant properties.

yearjournalcountryeditionlanguage
2022-10-25
10.3390/antibiotics11111468https://hdl.handle.net/10447/584170