6533b861fe1ef96bd12c4371

RESEARCH PRODUCT

Induction of tolerogenic DCs: ‘you are what you eat’

Juergen KnopKarsten MahnkeAlexander Enk

subject

Antigen PresentationbiologyEffectorImmunologyIntegrinModels ImmunologicalPeripheral tolerancechemical and pharmacologic phenomenaDendritic CellsImmune receptorReceptors AntigenImmune systemAntigenImmunologyImmune Tolerancebiology.proteinAnimalsHumansImmunology and AllergyReceptorAntigen-presenting cellSignal Transduction

description

Abstract Dendritic cells (DCs) take up antigens using antigen receptors that can be divided into three major classes: C-type lectins, integrins and Fc receptors. These receptors facilitate effective presentation of MHC–peptide complexes to T cells, resulting in the induction of immune responses. However, we discuss recent evidence that some receptors also cause induction of tolerance. Signaling motifs within the receptors either block maturation of DCs or induce signals that render DCs tolerogenic. These DCs then either induce regulatory T cells or cause deletion of effector T cells, resulting in the induction of tolerance. Antigen receptors expressed by DCs might therefore have an important role in the induction and maintenance of peripheral tolerance.

yearjournalcountryeditionlanguage
2003-12-03Trends in Immunology
https://doi.org/10.1016/j.it.2003.09.012