Synthesis of Combretastatin A-4 and 3′-Aminocombretastatin A-4 derivatives with Aminoacid Containing Pendants and Study of their Interaction with Tubulin and as Downregulators of the VEGF, hTERT and c-Myc Gene Expression

6533b861fe1ef96bd12c44e6

RESEARCH PRODUCT

Synthesis of Combretastatin A-4 and 3′-Aminocombretastatin A-4 derivatives with Aminoacid Containing Pendants and Study of their Interaction with Tubulin and as Downregulators of the VEGF, hTERT and c-Myc Gene Expression

Raquel Gil-edo J. Alberto Marco Eva Falomir Juan Murga Celia Martín-beltrán Raül Agut Miguel Carda Alberto Pla

subject

Vascular Endothelial Growth Factor A Cell cycle checkpoint <i>htert</i>Pharmaceutical Science Apoptosis Analytical Chemistry chemistry.chemical_compound 0302 clinical medicine Drug Discovery Stilbenes c-<i>myc</i>Telomerase 0303 health sciences <i>vegf</i>biology Neovascularization Pathologic Chemistry 3′-aminocombretastatin a-4 Cell cycle <i>c-Myc</i>VEGF c-Myc Biochemistry Chemistry (miscellaneous)030220 oncology & carcinogenesis MCF-7 Cells Molecular Medicine cytotoxicity cell cycle hTERT HT29 Cells Article Proto-Oncogene Proteins c-myc microtubules lcsh:QD241-441 03 medical and health sciences Structure-Activity Relationship lcsh:Organic chemistry Microtubule Cell Line Tumor Humans Physical and Theoretical Chemistry 030304 developmental biology Cell Proliferation Combretastatin Combretastatin A-4 Cell growth Organic Chemistry Antineoplastic Agents Phytogenic Tubulin tubulin Cell culture A549 Cells biology.protein M Phase Cell Cycle Checkpoints combretastatin a-4 Drug Screening Assays Antitumor

description

Natural product combretastatin A-4 (CA-4) and its nitrogenated analogue 3&prime

year	journal	country	edition	language
2020-02-04	Molecules

10.3390/molecules25030660 https://www.mdpi.com/1420-3049/25/3/660

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