6533b861fe1ef96bd12c44f1
RESEARCH PRODUCT
Synthesis of Hybrid Tripeptide Peptidomimetics Containing Dehydroamino Acid and Aminophosphonic Acid in the Chain and Evaluation of Their Activity toward Cathepsin C
Michał Paweł JewgińskiMaciej MakowskiMałgorzata PawełczakWaldemar GoldemanAlicja Trojanowska‐laskowskaPaweł KafarskiRafał Latajkasubject
phosphonopeptidesmolecular modelingMolecular ConformationBioengineeringGeneral ChemistryGeneral MedicineBiochemistryCathepsin Cdehydropeptidesstructure-activity relationinhibitorsMolecular MedicinePeptidomimeticsDPPIPeptidesMolecular Biologydescription
Synthesis of a new group of hybrid phosphonodehydropeptides composed of glycyl-(Z)-dehydrophenylalanine and structurally variable aminophosphonates alongside with investigations of their activity towards cathepsin C are presented. Obtained results suggest that the introduction of (Z)- dehydrophenylalanine residue into the short phosphonopeptide chain does induce the ordered conformation. Investigated peptides appeared to act as weak or moderate inhibitors of cathepsin C.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2021-12-23 | Chemistry & Biodiversity |