Sintētisko miRNS ietekme uz zarnu mikrobioma kompozīciju 2. tipa cukura diabēta peļu modelī

6533b861fe1ef96bd12c48df

RESEARCH PRODUCT

Sintētisko miRNS ietekme uz zarnu mikrobioma kompozīciju 2. tipa cukura diabēta peļu modelī

Nanija Lība Zukule

subject

sintētiskas miRNS peļu modelis zarnu mikrobioms otrā tipa cukura diabēts Bioloģija

description

Zarnu mikrobioma kompozīcijas izmaiņas tiek asociētas ar dažādām slimībām, tostarp otrā tipa cukura diabētu (T2D). Interese par T2D ārstēšanu, regulējot mikrobiomu, ir strauji augusi. Ir pierādīts, ka miRNS spēj tieši saistīties pie baktērijām, tādējādi ietekmējot to sastopamību. Lai noskaidrotu, vai un kā miRNS ietekmē mikrobioma sastāvu un diabēta izpausmes diētas ierosinātā T2D peļu modelī, tām tika orāli nodrošināta nedēļu ilga dažādu miRNS terapija, kam sekoja fēču metagenoma sekvencēšana. Pelēm, kas saņēma paaugstināta tauku satura barību, miRNS terapijas ietekmē izmainījās zarnu mikrobioma kompozīcija. Pēc miR-141-3p terapijas atšķirīgi sastopami bija Eggerthellaceae, Clostridiales, Enterococcus un Enterorhabdus pārstāvji, taču diabēta izpausmes netika būtiski ietekmētas.

year	journal	country	edition	language
2022-01-01

https://dspace.lu.lv/dspace/handle/7/59243

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