6533b861fe1ef96bd12c4d45
RESEARCH PRODUCT
Chemical and enzymatic synthesis of glycopeptides
M. SchultzHorst Kunzsubject
chemistry.chemical_classificationChemistrySide chainPeptideContext (language use)Enzymatic synthesisCombinatorial chemistryGlycopeptidedescription
Progress recently made in the synthesis of biologically relevant N- and O-glycopeptides is illustrated by examples. In this context, developments in the preparation of complex saccharide side chains and in the subsequent coupling to peptide portions is described. Special emphasis is given to the synthesis of Lewis antigen-type structures. Furthermore, modern methods in solid phase peptide syntheses utilizing glycosylated building blocks are presented. Recent advances in glycopeptide syntheses employing enzymatic methods in deprotection steps as well as in peptide/saccharide chain elongation are reported.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1995-01-01 |