6533b861fe1ef96bd12c4d85

RESEARCH PRODUCT

Tyrosine hydroxylase Val-81-Met polymorphism associated with early-onset alcoholism

Armin SzegediNorbert DahmenChristoph HiemkeMarkus VölpPeter Singer

subject

Adultmedicine.medical_specialtyGenotypeTyrosine 3-MonooxygenaseMutation MissensePolymerase Chain ReactionPolymorphism Single Nucleotidechemistry.chemical_compoundMethionineReference ValuesInternal medicineGenotypeGeneticsHumansMedicineMissense mutationAge of OnsetAlleleBiological PsychiatryGenetics (clinical)DNA PrimersEarly onsetMethionineBase SequenceTyrosine hydroxylasebusiness.industryAlcohol dependenceValineAlcoholismPsychiatry and Mental healthEndocrinologychemistryAge of onsetbusinessPolymorphism Restriction Fragment Length

description

The present study examined the association of the Tyrosine hydroxylase Val-81-Met polymorphism with alcohol dependence. One hundred and fifty-nine patients in a psychiatric unit with alcohol dependence were genotyped as well as 92 healthy volunteers. The Val allele was more frequent in patients with alcohol dependence (69.5%) than in controls (62.5%). This effect was largely due to the association with early-onset alcoholism (77.8%), whereas no difference was noted between late-onset patients and controls. Our results suggest a role for tyrosine hydroxylase in early-onset alcoholism.

yearjournalcountryeditionlanguage
2005-02-22Psychiatric Genetics
https://doi.org/10.1097/00041444-200503000-00003